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Itrakonazol, ketokonazol i u manjoj meri flukonazol i vorikonazol su snažni inhibitori izoenzima CYP3A4 citohroma P450 i mogu pove?ati koncentraciju benzodiazepina u plazmi.Fenobarbital uzet istovremeno može dovesti do aditivnog efekta na CNS. Pove?an je rizik od sedacije i respiratorne depresije. Poznato je da fenobarbital indukuje CYP3A4 enzim
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